In Silico Approach for Pro-inflammatory Protein Interleukin 1β and Interleukin-1 Receptor Antagonist Protein Docking as Potential Therapy for COVID-19 Disease

Background: Interleukin-1 receptor antagonist (IL-1Ra) also known as Anakinra is a of IL-1 especially IL-1β. IL-1β increased in infected COVID-19 patient groups. This study aimed that the IL-1Ra contained Conditioned Medium Wharton’s Jelly Mesenchymal Stem Cells (CM-WJMSCs) has potential to inhibit which one cytokine storms occur COVID patients through an in-silico approach. Objective: aims determine effect silico approach pro-inflammatory protein interleukin 1β (IL-1 β) and interleukin-1 WJ-MSCs for treatment disease. Methods: 3D structure using homology modeling method on Swiss Model web-server. Molecular docking was performed analyze binding mode related with results were fixed FireDock Results: These proteins between CM-WJMSCs component, namely showed criteria such good score QMEAN, CscoreLB, BS-score results, lowest energy obtained -585.1 KJ/mol. It can be predicted causes patients. Conclusion: So there severity Covid-19 infection.